Table 5.
Distribution of mutation in genes detected by Xpert MTB/XDR assay among INH, FLQ, AMG, and ETH-resistant isolates
| Drugs | Mutation detected in gene target | No. of isolates | % |
|---|---|---|---|
| INH (n = 278) | Only inhA promoter | 36 | 12.9 |
| Only katG | 169 | 60.8 | |
| Only fabG1 | 1 | 0.4 | |
| Only oxyR-ahpC intergenic region | 2 | 0.7 | |
| inhA promoter and katG | 20 | 7.2 | |
| inhA promoter and fabG1 | 3 | 1.1 | |
| inhA promoter and oxyR-ahpC intergenic region | 8 | 2.9 | |
| katG and oxyR-ahpC intergenic region | 35 | 12.6 | |
| katG and fabG1 | 1 | 0.4 | |
| inhA promoter, fabG1 and oxyR-ahpC intergenic region | 1 | 0.4 | |
| inhA promoter, katG and oxyR-ahpC intergenic region | 2 | 0.7 | |
| FLQ (n = 103) | Only gyrA | 100 | 97.1 |
| Only gyrB | 1 | 1.0 | |
| Both gyrA and gyrB | 2 | 1.9 | |
| AMG (n = 7) | rrs | 6 | 85.7 |
| eis promoter | 1 | 14.3 | |
| ETH (n = 68) | inhA promoter | 68 | 100.0 |
INH isoniazid, FLQ fluoroquinolones, AMG aminoglycoside, ETH ethionamide