Table 2.

SAR Studies of naphthalene ring region

Compounds	R3	IC50 (μg/mL)a,b	clogPc
8		n.a.	7.4
9		3.48	5.3
10		0.07	7.1
11		1.00	6.5
12		2.60	6.2
13		n.a.	5.8
14		2.08	5.9
15		n.a.	6.3
16		n.a.	4.1
17a		2.09	4.5
18a		1.88	3.2
19		n.a.	3.6
20		n.a.	4.6
21		n.a.	4.6
22		n.a.	4.5
23		4.00	6.4
24		n.a.	6.0
25		n.a.	6.9
26		n.a.	6.6
27		n.a.	6.3

^aIC₅₀ is calculated based on the relative inhibition rate of compounds against the wild-type strain at different concentrations, dose–response curve was shown in Fig. 4 and Supplementary Fig. 2.

^bn.a. means that IC₅₀ cannot be calculated and given from the response curve within the test range.

^cclogP data were calculated by software Chemdraw.