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. 2025 Mar 31;13:1505935. doi: 10.3389/fped.2025.1505935

Table 5.

Fixed effect estimates from the linear mixed-effects model for the impact of EEN on CRP and CHE.

Variables CRP CHE
Estimate Std. error t value P value Estimate Std. error t value P value
Intercept 47.98 6.67 7.19 <0.001 3,422.41 384.57 8.89 <0.001
EEN 2.04 5.82 0.35 0.716 −695.34 326.42 −2.13 0.034
Time (day) −1.00 0.66 −1.51 0.133 −12.24 34.85 −0.35 0.726
PRISM3 −0.43 0.31 −1.39 0.167 −1.54 18.17 −0.08 0.933
EEN:Time −3.69 0.93 −3.95 <0.001 411.47 48.77 8.43 <0.001

The table presents the fixed effect estimates from the linear mixed-effects model for CRP and CHE, evaluating the impact of EEN, time, their interaction (EEN:Time), and PRISM3 on CRP and CHE levels. CRP represents C-reactive protein (mg/L), CHE represents cholinesterase (U/L), and PRISM3 represents the pediatric risk of mortality 3 score. EEN is a binary variable indicating whether early enteral nutrition (EEN) was received or not. Time represents the number of observation days (from Day 1 to Day 7). PRISM3 is a covariate used to adjust for baseline disease severity. The EEN: Time interaction effect indicated the differences in the changes of CRP and CHE levels over time between the EEN and LEN groups. A P-value of less than 0.05 indicates statistical significance.