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. 2005 Sep 2;33(15):4914–4921. doi: 10.1093/nar/gki799

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Effect of ccnd1 knockdown on morphology of zebrafish embryos. Photomicrographs demonstrate the morphology of zebrafish embryos following knockdown of cyclin D1 at 24 h after microinjection with 0.1–1 mM ccnd1 antisense MO or HypNA-pPNA: (A) Uninjected control; (B) MO-treated embryo; (C) HypNA-pPNA-treated embryo; (D) Phenol Red control; (E) MO 3-base mismatch control; and (F) HypNA-pPNA 1-base mismatch control; all images were taken at ×100 magnification. The embryos injected with either antisense oligonucleotide displayed microophthalmia and microcephaly consistent with the restricted expression of cyclin D1 in 24 hpf zebrafish embryos. No gross morphologic defect was observed in the mismatch control-injected embryos. Labels: h, head; e, eye; y, yolk sac; b, body.