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. 2005 Sep 1;19(17):1986–1999. doi: 10.1101/gad.342305

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Copyright © 2005, Cold Spring Harbor Laboratory Press

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Figure 1. — Life span is decreased in p63^+/- mice. (A) Over the course of a >2.2-yr study, the median life span for wild-type mice (n = 74) was 121 wk, whereas that of p63^+/- mice (n = 104) was 95 wk, a difference of 21.5% (P < 0.0001, log-rank test). p63^+/- mice frequently developed hyperplastic lesions in a variety of epithelia. (B-G) Histological analysis of tissues of p63^+/- mice. (B) Dorsal back skin. (C) Dorsal surface of the tongue. (D) Rectum. (E) Vagina. (F) Cornea of the eye. (G) Glomerulus of the kidney.