Table 3.

Lifetime additional benefits and harms of screening mammography starting at age 40 instead of 50 until age 74 per 1,000 women from six models

Initial Strategy	Comparison Strategy	Model
		D	E	GE	M	S	W	Median	Range
Mammograms
DM B50–74	DM B40–74	4,936	4,900	4,924	4,869	a	4,864	4,900	4,864 – 4,936
DBT B50–74	DBT B40–74	4,936	4,895	4,924	4,870	4,920	4,850	4,907	4,850 – 4,936
Percent breast cancer mortality reduction
DM B50–74	DM B40–74	4.1%	4.1%	8.6%	6.5%	a	3.1%	4.1%	3.1 – 8.6%
DBT B50–74	DBT B40–74	4.4%	4.3%	8.6%	6.4%	4.9%	3.6%	4.6%	3.6 – 8.6%
Breast cancer deaths averted
DM B50–74	DM B40–74	1.3	1.2	3.2	1.5	a	0.8	1.3	0.8 – 3.2
DBT B50–74	DBT B40–74	1.4	1.3	3.2	1.5	1.2	0.9	1.3	0.9 – 3.2
Life-years gained
DM B50–74	DM B40–74	43.1	35.3	102.7	53.3	a	31.4	43	31.4 – 102.7
DBT B50–74	DBT B40–74	46.1	36.5	102.9	52.3	27.0	36.3	41	27.0 – 102.9
False-positive recalls
DM B50–74	DM B40–74	523	520	521	514	a	517	520	514 – 523
DBT B50–74	DBT B40–74	506	502	504	493	505	499	503	493 – 506
Benign biopsies
DM B50–74	DM B40–74	63	62	62	60	a	62	62	60 – 63
DBT B50–74	DBT B40–74	66	65	66	62	66	65	65	62 – 66
Overdiagnosed cases (DCIS and invasive)
DM B50–74	DM B40–74	1	2	0	3	a	4	2	0 – 4
DBT B50–74	DBT B40–74	1	2	0	3	a	4	2	0 – 4

Abbreviations: A, annual; B, biennial; D, Dana-Farber Cancer Institute; DBT, digital breast tomosynthesis; DM, digital mammography; E, Erasmus Medical Center; GE, Georgetown Lombardi Comprehensive Cancer Center-Albert Einstein College of Medicine; M, University of Texas MD Anderson Cancer Center; S, Stanford University; W, University of Wisconsin-Madison and Harvard Pilgrim Health Care Institute.

^aNot available