Figure 1.

Changes due to chemotherapy in biopsies taken before and after chemotherapy. Cytotoxicity of a) doxorubicin; b) mitoxantrone; c) topotecan; d) paclitaxel and e) cisplatin (expressed as IC50 μM) in paired samples obtained from ovarian cancer patients before and after they were treated with an anthracycline containing regimen (paclitaxel+mitoxantrone n = 7; liposomal doxorubicin n = 2). Each line represents an individual patient. (f) Gene expression changes pre- and post-treatment (paclitaxel plus mitoxantrone chemotherapy) in one patient were analysed by qRT-PCR following in vitro exposure to doxorubicin.