Table 7.

Relative expression of mRNA levels in tumor samples after ex vivo exposure to 5 FU. The IC₅₀ concentrations for the samples tested are shown for each drug (median and range). The p values have been calculated using non-parametric statistics, in detail the Wilcoxon matched pairs test. On statistical advice, we chose not to use a Bonferroni's correction, but it should be noted that some technically statistically significant results could have arisen by chance.

	Breast samples IC50 = 200 μM (86.5–363)				Colorectal samples IC50 = 112 μM (13.8–311)
Target gene	n	Control	5-FU	p	n	Control	5-FU	p
DPD	13	1.289	0.494	0.0012	10	0.503	0.448	0.4922
TP	13	8.876	10.928	0.6848	10	4.616	5.963	0.084
TS	13	1.136	3.819	0.0005	10	2.157	7.954	0.002