. 2025 Apr 11;13:e19271. doi: 10.7717/peerj.19271

Table 4. Associations between ADCY3 gene rs2241759 polymorphism and the baseline blood lipid profiles.

Blood lipids	Variable	n	AA (mmol\L)	AG (mmol\L)	GG (mmol\L)	Major allele	TEST	β	P
TC	Total	237	3.978 ± 0.640	3.990 ± 0.633	3.953 ± 0.630	G	ADD	0.044	0.419
	Male	109	3.978 ± 0.638	3.984 ± 0.637	3.943 ± 0.626	G	ADD	−0.048	0.071
	Female	128	4.008 ± 0.615	4.009 ± 0.616	3.979 ± 0.622	G	ADD	0.017	0.415
HDL-C	Total	237	1.505 ± 0.364	1.517 ± 0.361	1.528 ± 0.367	G	ADD	−0.018	0.726
	Male	109	1.505 ± 0.363	1.514 ± 0.362	1.525 ± 0.370	G	ADD	−0.019	0.040^*
	Female	128	1.541 ± 0.358	1.541 ± 0.359	1.565 ± 0.364	G	ADD	0.033	0.288
LDL-C	Total	237	2.400 ± 0.455	2.404 ± 0.453	2.384 ± 0.450	G	ADD	0.948	0.430
	Male	109	2.400 ± 0.455	2.398 ± 0.455	2.381 ± 0.450	G	ADD	0.491	0.232
	Female	128	2.409 ± 0.447	2.410 ± 0.446	2.391 ± 0.452	G	ADD	−0.015	0.368
TG	Total	237	1.233 ± 0.444	1.233 ± 0.446	1.222 ± 0.436	G	ADD	−0.030	0.989
	Male	109	1.233 ± 0.444	1.234 ± 0.449	1.222 ± 0.436	G	ADD	0.014	0.347
	Female	128	1.218 ± 0.431	1.217 ± 0.432	1.214 ± 0.457	G	ADD	−0.065	0.105

Notes.

P < 0.05.