Table 5.
Association between congenital toxoplasmosis and developmental outcomes: multivariable analyses
| Developmental outcome (Odds ratio and 95% confidence interval) | ||||
| PARENT COMPLETED | ||||
| Motor | Speech & language | Behaviour | Cognition | |
| All centres (N = 705) | 1.30 (0.75, 2.25)2 | 1.10 (0.60, 2.02) 3,4 | 1.05 (0.66, 1.67) 2 | 0.85 (0.35, 2.09) |
| Sensitivity analyses | ||||
| a) France only (N = 379)1 | 1.22 (0.61, 2.42)2 | 0.98 (0.45,2.14) | 1.15 (0.64, 2.09) | 0.55 (0.17, 1.76)2 |
| b) Poland only (N = 134) | 1.10 (0.30, 4.06) | 0.54 (0.13, 2.26) | 0.94 (0.30, 2.92) | 1.02 (0.16, 6.62) |
| c) Children aged 36 to <41 months (N = 553) | 1.18 (0.68, 2.05) | 1.04 (0.54, 2.00) | 1.25 (0.70, 2.22) | 0.61 (0.25, 1.50) |
| d) Children with no signs before 4 months (N = 538 Poland excluded) | 1.08 (0.57, 2.07) | 1.10 (0.51, 2.36) | 1.02 (0.57, 1.82)2 | 0.35 (0.10, 1.24) |
| CHILD COMPLETED | ||||
| 'Draw a Man' | Line, circle, cross | |||
| All centres (N = 705) | 1.27 (0.66, 2.44)5 | 1.13 (0.56, 2.25) | ||
| Sensitivity analyses | ||||
| a) France only (N = 379)1 | 0.77 (0.35, 1.67) | 0.93 (0.40, 2.18) | ||
| b) Poland only (N = 134) | 1.00 (0.17, 5.77) | 0.76 (0.13, 4.41) | ||
| c) Children aged 36 to <41 months (N = 553) | 0.79 (0.39, 1.63)5 | 0.96 (0.48, 1.95) | ||
| d) Children with no signs before 4 months (N = 538 Poland excluded) | 0.96 (0.46, 2.02) | 1.03 (0.45, 2.36) | ||
All models include centre, maternal education, and child's age at completion of questionnaire
1adjusts for variability among centres relative to Lyon
2adjusted for maternal age
3adjusted for born outside the country
4adjusted for maternal age
5adjusted for gender, and maternal age squared