Table 3.

Summarize the regulatory factors involved in NF-κB-mediated pyroptosis in OA.

Regulatory element	Signaling Pathway	Biological function	Animal models	Reference
Mechanical stress	TGF-β/Smad2/3/NF-κB	Inhibit chondrocyte pyroptosis	Rats	(143)
Ursolic acid	NF-κB/NLRP3	Inhibits cartilage degradation	Rats	(145)
GYY4137	NF-κB/NLRP3	Inhibits synovial macrophagic pyroptosis	Mice	(146)
Loganin	NF-κB/Caspase-1	Inhibits cartilage degradation	Mice	(147)
α-Solanine	NF-κB/NLRP3	Reduces osteophyte formation and subchondral sclerosis	Mice	(148)
Resolvin D1	NF-κB/NLRP3/Caspase-1	Promotes chondrocyte proliferation and repair	Rats	(149)
SPD	NF-κB/NLRP3/Caspase-1	Promote the cartilage integrity and suppress ECM	Rats	(150)
PD0325901	NF-κB/NLRP3	Inhibits subchondral bone destruction	Mice	(151)
Less mechanical loading	NF-κB/NLRP3	Inhibits cartilage degradation, subchondral bone remodeling	Rats	(152)