Table 4.
Summarize the regulatory factors involved in P2X7R-mediated pyroptosis in OA.
| Regulatory element | Possible signaling Pathway | Biological function | Animal models | Reference |
|---|---|---|---|---|
| A740003 | P2X7R | Inhibiting ATP-induced pyroptosis | Mice | (62) |
| ATP | P2X7R/Caspase-3/7 | Inhibiting cartilage damage | Rabbits | (155) |
| Linear Ubiquitination of LKB1 | AMPK/NLRP3 | Ameliorated inflammasome response and chondrocyte injury | Rats | (160) |
| Piperine | ATP/AMPK/mTOR | Inhibition of macrophage pyroptosis | Mice | (161) |
| Rapamycin | mTOR | Inhibit autophagy of articular chondrocytes | Mice | (163) |
| Gu yan xiao tincture | mTOR | Alleviate tissue damage in rabbit models of OA | Rabbits | (164) |
| MHY1485 | mTOR | Promote ECM degradation and cartilage injury | Mice | (165) |
| Moderate exercise | P2X7/AMPK/mTOR | Promote autophagy in OA to alleviate pyroptosis | Rats | (167) |