Table 5.
Summarize the regulatory factors involved in Nrf2/HO-1 and HIF-1α-mediated pyroptosis in OA.
| Regulatory element | Signaling Pathway | Biological function | Animal models | Reference |
|---|---|---|---|---|
| Oroxylin A | Lcp1/HIF-1α | Decreased subchondral bone remodeling and slowed cartilage degeneration | Mice | (130) |
| PD184352 | Nrf2/HO-1 | Anti-inflammatory and antioxidant effects | Mice | (171) |
| Myrislignan | Nrf2/HO-1 | Inhibits inflammation and oxidative stress | Rats | (172) |
| HMGB1 | HO-1/VEGF | Inhibits synovial angiogenesis | Human FLS | (176) |
| Silence HIF-1α | HIF-1α/NLRP3 | Inhibit pyroptosis of FLS | Rats | (177) |
| Agnuside(AGN) | HIF-1α/NLRP3 | Relieves synovitis and fibrosis in KOA | Rats | (178) |