. 2025 Apr 14;16:3525. doi: 10.1038/s41467-025-58506-x

Table 5.

Comparison summary of top variants exhibiting genome-wide significance for the TyG index, TG:HDL-C index, and glucose levels, identified within the Taiwan Biobank (sorted by gene)

TyG				TG:HDL-C				Glucose
CHR	GENE	SNP	P	Chr	GENE	SNP	P	Chr	GENE	SNP	P
11	APOA1^a	rs10750098	4.3E-150	11	APOA1^a	rs10750098	9E-99	2	ABCB11	rs139014876	1.8E-209
11	APOA4	rs5104	1.1E-235	11	APOA4	rs5104	2E-191	7	AGMO^a	rs6947830	5.2E-59
19	APOC1	rs5117	2.8E-111	19	APOC1	rs5117	2E-101	7	CAMK2B	rs732360	3.6E-140
11	APOC3	rs5128	2.8E-152	11	APOC3	rs5128	2E-100	6	CDKAL1	rs34499031	3.0E-51
19	APOE	rs440446	1.7E-106	19	APOE	rs429358	8E-112	9	CDKN2B^a	rs10811661	5.1E-68
7	BAZ1B	rs111837003	1.2E-71	7	BAZ1B	rs111837003	7.3E-55	20	FOXA2	rs3833331	3.6E-92
7	BCL7B	rs7793710	1.1E-83	7	BCL7B	rs7793710	3.6E-62	2	G6PC2	rs2232326	1.9E-235
2	C2orf16	rs1919127	6.9E-114	2	C2orf16	rs1919127	6.3E-73	7	GCK	rs2908289	2.9E-161
7	FZD9	rs1178947	5.8E-69	16	CETP	rs12720926	3.3E-61	2	GCKR	rs1260326	6.8E-60
2	GCKR	rs1260326	4.3E-204	7	FZD9	rs1178947	6.6E-54	9	KANK1	rs16922302	2.6E-51
2	GPN1	rs34502053	7.9E-68	2	GCKR	rs1260326	7E-140	20	LINC00261	rs6113722	4.1E-89
8	LPL	rs75278536	2.0E-153	8	LPL	rs12679834	6E-171	20	LOC101929685	rs6048211	3.6E-88
7	MLXIPL	rs3812316	8.5E-105	7	MLXIPL	rs3812316	4.3E-78	11	MTNR1B	rs10830963	5.5E-144
19	NECTIN2	rs283811	1.6E-94	19	NECTIN2	rs283811	5.7E-97	7	MYL7	rs741033	3.9E-58
11	PAFAH1B2	rs7925256	8.0E-75	11	PAFAH1B2	rs117592676	3.8E-68	2	NOSTRIN	rs143166986	1.2E-90
11	SIK3	rs6589574	1.2E-112	11	SIK3	rs199986368	3.4E-71	7	POLD2	rs3087370	2.5E-57
8	SLC18A1^a	rs9644568	2.8E-90	8	SLC18A1^a	rs9644568	2E-106	2	SIX3^a	rs12712928	1.4E−126
7	TBL2	rs13246490	2.6E-84	7	TBL2	rs12540011	1.1E-62	8	SLC30A8	rs13266634	4.3E-95
19	TOMM40	rs157582	7.5E-94	19	TOMM40	rs10119	1E-103	2	SPC25	rs493816	2.2E-102
2	ZNF512	rs12989678	1.3E-115	2	ZNF512	rs12989678	1.1E-74	7	YKT6	rs2971667	8.1E-159

^aNearby gene. This GWAS analysis utilized BOLT-LMM’s mixed linear models with a two-sided chi-square test. The conventional genome-wide significance threshold of P < 5 × 10⁻⁸ was applied.