Table 7.
The association of disease phenotypes with the TyG index, TG:HDL ratio, PRS of the TyG index, and PRS of the TG:HDL ratio
| ‘ | TyG index | TG:HDL-C | PRS of TyG index | PRS of TG:HDL-C | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease | N (%) | Case | Control | P | Case | Control | P | Case | Control | P | Case | Control | P |
| Osteoporosis | 1635 (4.01) | 8.43 (0.52) | 8.38 (0.56) | 0.0002 | 2.11 (1.52) | 2.22 (1.68) | 0.0058 | −0.04 (1.01) | 0.00 (1.00) | 0.1199 | −0.03 (0.99) | 0.00 (1.00) | 0.1499 |
| Arthritis | 1973 (4.84) | 8.47 (0.52) | 8.38 (0.56) | <0.0001 | 2.23 (1.54) | 2.22 (1.69) | 0.7792 | −0.01 (0.99) | 0.00 (1.00) | 0.6785 | −0.01 (0.97) | 0.00 (1.00) | 0.5976 |
| Gout | 1458 (3.58) | 8.76 (0.53) | 8.37 (0.55) | <0.0001 | 3.46 (2.23) | 2.17 (1.64) | <0.0001 | 0.08 (0.98) | −0.00 (1.00) | 0.0016 | 0.08 (0.98) | −0.00 (1.00) | 0.001 |
| Asthma | 1519 (3.73) | 8.38 (0.55) | 8.38 (0.56) | 0.9077 | 2.22 (1.66) | 2.22 (1.68) | 0.899 | −0.00 (0.99) | 0.00 (1.00) | 0.9353 | −0.02 (0.98) | 0.00 (1.00) | 0.4724 |
| Emphysema bronchitis | 499 (1.22) | 8.43 (0.53) | 8.38 (0.56) | 0.0595 | 2.27 (1.76) | 2.22 (1.68) | 0.469 | −0.03 (0.99) | 0.00 (1.00) | 0.4625 | −0.04 (0.96) | 0.00 (1.00) | 0.383 |
| Coronary heart disease | 4087 (10.03) | 8.41 (0.54) | 8.38 (0.56) | <0.0001 | 2.23 (1.64) | 2.21 (1.68) | 0.5341 | 0.00 (0.99) | −0.00 (1.00) | 0.9633 | −0.02 (1.00) | 0.00 (1.00) | 0.2719 |
| Valve heart disease | 1827 (4.48) | 8.31 (0.53) | 8.38 (0.56) | <0.0001 | 1.98 (1.51) | 2.23 (1.69) | <0.0001 | −0.01 (1.01) | 0.00 (1.00) | 0.6366 | −0.03 (1.01) | 0.00 (1.00) | 0.2179 |
| Coronary Artery Disease | 524 (1.29) | 8.66 (0.52) | 8.38 (0.56) | <0.0001 | 2.89 (1.91) | 2.21 (1.67) | <0.0001 | 0.13 (0.97) | −0.00 (1.00) | 0.0035 | 0.09 (0.96) | −0.00 (1.00) | 0.0454 |
| Arrhythmia | 1836 (4.50) | 8.43 (0.53) | 8.38 (0.56) | 0.0001 | 2.21 (1.54) | 2.22 (1.68) | 0.9548 | −0.02 (0.99) | 0.00 (1.00) | 0.323 | −0.04 (1.00) | 0.00 (1.00) | 0.106 |
| Cardiomyopathy | 334 (0.82) | 8.62 (0.55) | 8.38 (0.56) | <0.0001 | 2.84 (2.03) | 2.21 (1.67) | <0.0001 | −0.06 (1.04) | 0.00 (1.00) | 0.2711 | −0.05 (1.03) | 0.00 (1.00) | 0.3761 |
| Hyperlipidemia | 2891 (7.09) | 8.73 (0.54) | 8.35 (0.55) | <0.0001 | 3.06 (2.08) | 2.15 (1.63) | <0.0001 | 0.24 (1.04) | −0.02 (0.99) | <0.0001 | 0.21 (1.05) | −0.02 (0.99) | <0.0001 |
| Hypertension | 4684 (11.49) | 8.68 (0.51) | 8.34 (0.55) | <0.0001 | 2.92 (1.90) | 2.12 (1.63) | <0.0001 | 0.04 (1.01) | −0.00 (1.00) | 0.0058 | 0.03 (1.00) | −0.00 (1.00) | 0.0194 |
| Apoplexia | 271 (0.66) | 8.53 (0.55) | 8.38 (0.56) | <0.0001 | 2.64 (1.85) | 2.21 (1.68) | 0.0002 | −0.03 (1.07) | 0.00 (1.00) | 0.6692 | −0.01 (1.06) | 0.00 (1.00) | 0.8817 |
| Diabetes | 1683 (4.13) | 8.83 (0.52) | 8.36 (0.55) | <0.0001 | 3.03 (1.93) | 2.18 (1.66) | <0.0001 | 0.06 (0.99) | −0.00 (1.00) | 0.0137 | 0.05 (1.00) | −0.00 (1.00) | 0.0424 |
| Gastrointestinal | 9500 (23.31) | 8.42 (0.55) | 8.37 (0.56) | <0.0001 | 2.26 (1.69) | 2.20 (1.67) | 0.0015 | 0.00 (0.99) | −0.00 (1.00) | 0.7086 | −0.01 (1.00) | 0.00 (1.00) | 0.427 |
| Peptic ulcer | 5859 (14.38) | 8.43 (0.54) | 8.37 (0.56) | <0.0001 | 2.27 (1.68) | 2.21 (1.68) | 0.004 | 0.01 (1.00) | −0.00 (1.00) | 0.4851 | −0.00 (1.00) | 0.00 (1.00) | 0.422 |
| Gastroesophageal reflux | 5674 (13.92) | 8.41 (0.55) | 8.37 (0.56) | <0.0001 | 2.25 (1.67) | 2.21 (1.68) | 0.117 | −0.01 (1.00) | 0.00 (1.00) | 0.2397 | −0.02 (1.01) | 0.00 (1.00) | 0.1207 |
| Irritable bowel syndrome | 1034 (2.54) | 8.40 (0.56) | 8.38 (0.56) | 0.2199 | 2.25 (1.69) | 2.22 (1.68) | 0.5202 | −0.04 (0.98) | 0.00 (1.00) | 0.1835 | −0.03 (1.00) | 0.00 (1.00) | 0.283 |
| Mental disease | 1810 (4.44) | 8.42 (0.56) | 8.38 (0.56) | 0.0006 | 2.29 (1.71) | 2.21 (1.68) | 0.067 | 0.01 (1.01) | −0.00 (1.00) | 0.5375 | 0.02 (1.01) | −0.00 (1.00) | 0.4359 |
| Depression | 1460 (3.58) | 8.42 (0.56) | 8.38 (0.56) | 0.0025 | 2.27 (1.73) | 2.21 (1.68) | 0.1848 | −0.01 (1.01) | 0.00 (1.00) | 0.7788 | 0.00 (1.01) | −0.00 (1.00) | 0.9474 |
| Manic depression | 277 (0.68) | 8.50 (0.55) | 8.38 (0.56) | 0.0004 | 2.47 (1.76) | 2.21 (1.68) | 0.011 | 0.17 (1.01) | −0.00 (1.00) | 0.004 | 0.11 (1.01) | −0.00(1.00) | 0.0676 |
| Nervous system disease | 1360 (3.34) | 8.35 (0.56) | 8.38 (0.56) | 0.0785 | 2.11 (1.65) | 2.22 (1.68) | 0.017 | −0.02 (1.01) | 0.00 (1.00) | 0.3977 | −0.03 (1.00) | 0.00 (1.00) | 0.3298 |
| Hemicrania | 1174 (2.88) | 8.34 (0.56) | 8.38 (0.56) | 0.0115 | 2.06 (1.61) | 2.22 (1.68) | 0.0009 | −0.02 (1.02) | 0.00 (1.00) | 0.3922 | −0.03 (1.00) | 0.00 (1.00) | 0.2331 |
| Stone | 4172 (0.24) | 8.53 (0.54) | 8.36 (0.56) | <0.0001 | 2.58 (1.81) | 2.17 (1.66) | <0.0001 | 0.00 (0.99) | −0.00 (1.00) | 0.9289 | −0.00 (1.00) | 0.00 (1.00) | 0.8771 |
| Liver gall stone | 1871 (4.59) | 8.5 (0.53) | 8.37 (0.56) | <0.0001 | 2.46 (1.7) | 2.2 (1.68) | <0.0001 | 0.02 (0.99) | −0.00 (1.00) | 0.476 | 0.00 (0.99) | −0.00 (1.00) | 0.8524 |
| Kidney stone | 2490 (6.11) | 8.55 (0.55) | 8.37 (0.56) | <0.0001 | 2.69 (1.88) | 2.19 (1.66) | <0.0001 | −0.00 (0.99) | 0.00 (1.00) | 0.9761 | 0.00 (1.00) | −0.00 (1.00) | 0.9619 |
| Vertigo | 2524 (6.19) | 8.39 (0.53) | 8.38 (0.56) | 0.2181 | 2.12 (1.53) | 2.22 (1.69) | 0.001 | 0.03 (0.99) | −0.00 (1.00) | 0.1313 | 0.02 (0.99) | −0.00 (1.00) | 0.2213 |
PRS polygenic risk score, TG:HDL-C the ratio of triglycerides to high-density lipoprotein cholesterol TyG index the triglyceride-glucose index. The TyG index was derived using the formula Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Significant p values, denoted in bold, indicate statistical significance after applying the Bonferroni correction threshold of p = 0.00185 (obtained by dividing the conventional significance level of 0.05 by the number of tests conducted, which in this case is 27; 0.05/27 = 0.00185). Polygenic risk scores were generated with PRS-CS using Bayesian regression; subsequent two-sided linear regression tested associations.