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. 2025 Apr 14;16:3525. doi: 10.1038/s41467-025-58506-x

Table 8.

The summary of the pathway analysis results for the whole cohort, sex-specific cohorts, and genes from previous studies

Cohort Whole Female Male Previous
Adherens junction 5.31E-13 2.59E-02 6.39E-04 4.65E-14
Alzheimer’s disease 2.24E-26 1.70E-03 2.16E-02 3.25E-23
Cell cycle 1.80E-39 9.35E-06 1.18E-10 3.64E-37
Estrogen signaling pathway 6.79E-10 2.09E-11 - 8.21E-10
Glucose metabolism 3.95E-05 4.39E-02 - 2.31E-03
Insulin resistance 4.76E-10 - - 8.07E-16
Insulin signaling pathway 8.09E-14 - - 7.07E-22
Insulin secretion - 1.92E-02 - -
Neurodegeneration 1.91E-25 2.64E-06 7.79E-03 3.41E-23
Notch signaling 3.99E-03 9.98E-03 1.91E-02 1.50E-05
Nervous system development 2.49E-29 8.72E-11 7.29E-05 2.41E-43
Plasma lipoprotein assembly, remodeling, and clearance 4.64E-06 3.59E-02 - 1.90E-03
TGF-beta signaling pathway 4.92E-24 8.54E-09 3.84E-05 8.47E-24
Tight junction 2.36E-07 - 4.02E-03 4.78E-11
Wnt signaling pathway 1.30E-06 5.13E-06 6.74E-04 2.02E-08