Table 2.

Mitochondrial respiratory indexes in BJ fibroblasts expressing ERRAS. Coupling efficiency, spare respiratory capacity and respiratory control ratio were calculated, as described in Methods, considering the values shown in Fig. 4D. Results are the mean ± SD. Significant differences between senescent cells and the control condition were determined by one-way ANOVA ∗P < 0.05, ∗∗P < 0.001 (n = 4–5).

Indexes	Control	+4OHT
		Day 1	Day 6	Day 9
Coupling efficiency	0.7 ± 0.05	0.69 ± 0.01	0.74 ± 0.03	0.8 ± 0.04∗
Spare respiratory capacity	2.0 ± 0.1	2.1 ± 0.2	3.1 ± 0.2∗∗	3.4 ± 0.4∗∗
Respiratory control ratio	7 ± 1	7 ± 1	12 ± 2∗∗	17 ± 2∗∗