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. 2024 Dec 24;7(4):101311. doi: 10.1016/j.jhepr.2024.101311

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — HBV kinetics during infection and treatment.

PHHs were inoculated with 10 GEq/cell HBV. Cultures were either left untreated (UT) or treated with ETV, Myr-preS1, or ETV + Myr-preS1. Three samples were harvested at the indicated time points,and HBV DNA was quantified by qPCR. (A) Extracellular HBV DNA, (B) total intracellular HBV DNA, and (C) cccDNA. Data is graphed as mean ± SD. cccDNA, covalently closed circular DNA; ETV, entecavir; GEg, genome equivalents; inHBV, intracellular HBV DNA; Myr-preS1, myristoylated pre-S/2-48myr peptide; PHH, primary human hepatocyte; qPCR, quantitative real-time PCR.