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. 2025 Apr 1;68(7):7720–7736. doi: 10.1021/acs.jmedchem.5c00329

Figure 1.

Figure 1

Previously reported series of dual ACE/NEP mercaptoacyl dipeptides: (A) mercapto-3-phenylpropanoyl dipeptides23 and (B) mercapto-3-phenylpropanoyl-glycine 5-phenylprolines.31 (C) Overlay of the cACE-omapatrilat (green carbon atoms) co-crystal structure (PDB code 6H5W)32 with a dual ACE/NEP inhibitor ((S)-2-methyl-3-phenylpropanoyl)-l-alanyl-l-proline (orange carbon atoms) docked into the active site of cACE. The Schechter and Berger nomenclature is used for the S1 to S2′ subsites flanking the catalytic zinc.