Table 3. Comparison of the Overall Structures of nACE and cACE in Complex with AD014, AD015, and AD016 Inhibitors^a.

		nACE		cACE
		AD014	AD015	AD014	AD015	AD016
nACE	AD014		0.40	0.97	1.00	0.94
	AD015	0.40		0.90	0.93	0.88
cACE	AD014	0.97	0.90		0.24	0.26
	AD015	1.00	0.93	0.24		0.34
	AD016	0.94	0.88	0.26	0.34

^aRMSD values (Å) for 604, 578, and 573 Cα atoms between nACE structures, cACE structures, and nACE/cACE structures, respectively. Values were generated using the “Structure Alignment and Superposition with Gesamt” program on the CCP4 cloud.