TABLE 3.
Cytokine productivity of T lymphocytes in the spleen of M. pneumoniae-infected micea
| Stimulating strain | Infection | Mean concn (pg/ml) |
|||
|---|---|---|---|---|---|
| IL-2 | IL-4 | IL-10 | IFN-γ | ||
| No. 4 | Mock | 3.4 ± 1.5 | ND | 3.0 ± 0.2 | 5.6 ± 0.3 |
| Single | 7.3 ± 0.4 | ND | 22.3 ± 1.2∗∗ | 1.3 ± 0.1 | |
| Repeated | 21.6 ± 2.5∗ | 8.6 ± 1.8∗† | 86.1 ± 1.9∗∗ | 828.0 ± 171.4∗† | |
| FH | Mock | 4.8 ± 2.9 | ND | 2.7 ± 0.1 | ND |
| Single | 7.9 ± 1.1 | ND | 34.6 ± 1.7∗ | 4.1 ± 0.2 | |
| Repeated | 14.6 ± 4.2∗ | 14.5 ± 0.4∗∗ | 203.8 ± 30.3∗† | 1271.0 ± 244.6∗† | |
a
Each cytokine was analyzed by ELISA. Values are means ± standard deviation of the mean. ND, not detected. ∗, P <0.05 versus mock infection; †, P < 0.05 versus single infection. ∗∗, P <0.005 versus mock or single infection.