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MPDs and relative pyrogenic potencies of various pyrogens
| Pyrogen | MPDa (μg/kg) | Relative potencyb |
|---|---|---|
| Endotoxin | 0.0027 | 1 |
| PG | 7.3 | 0.00037 |
| SAC | 51 | 0.000053 |
| Poly(I · C) | 0.072 | 0.038 |
The MPD was defined as the minimum dose needed to cause a rise in body temperature of ≥0.6°C, as determined from the dose-response curve for each pyrogen (Fig. 2).
The pyrogenic potency is expressed relative to that of endotoxin.
