Fig. 1.

Morphology of differentiated ND7/23 cells following M-GFP infection. (A) Differentiated ND7/23 cells present long dendritic processes. (B, a-b) Culture of differentiated ND7/23 cells with acyclovir (ACV, 100 μM) for up to 4 d does not affect cell morphology or GFP expression. (C, a-b) Lytic infection of differentiated ND7/23 with M-GFP causes significant cell death and a reduction in dendritic outgrowth and GFP expression. (D-E, a-b) ACV-induced HSV-1 latency establishment in the presence or absence of TNF-α had minimal effect on dendritic outgrowth while showing GFP labeling of infected neurons. The arrows in Ca-b, Da-b, and Ea-b identify GFP-labeled cells