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. Author manuscript; available in PMC: 2025 Apr 15.
Published in final edited form as: J Neurovirol. 2024 Oct 4;30(5-6):513–523. doi: 10.1007/s13365-024-01229-4

Fig. 3.

Fig. 3

Effect of TTX on the Na+ currents generated in differentiated ND7/23 cells following latency establishment. (A) Examples of whole-cell Na+ currents generated in a differentiated ND7/23 cell following latency establishment and treatment with TNF-α in the presence of TTX. Note that the inward Na+ current generated in differentiated ND7/23 cells following latency establishment and treatment with TNF-α was eliminated by TTX (250 nM, arrow). (B) Comparison of cell capacitance in differentiated ND7/23 cells following latency establishment and treatment with TTX. (C) Overall effect of TTX on Na+ current densities in control (ACV-treated) cells and cells latently infected cells treated with TNF-α. TTX evokes a significant reduction in the current densities under all conditions tested. (* denotes p < 0.05 vs. ACV-treated cells; ** denotes p < 0.05 vs. ACV + M-GFP + TNF-α treated cells)