Fig. 5.

Effect of latency establishment and TNF-α treatment on viral replication and p38 signaling. (A) M-GFP infection of differentiated ND7/23 cells generates an increase in the expression of TK viral transcripts, which is reversed by ACV treatment. TNF-α does not have any effect on TK expression following latency establishment (* denotes p ≤ 0.05 vs. M-GFP-infected cells; n = 4). (B) TNF-α treatment of differentiated ND7/23 cells evokes a significant increase in p38 signaling, without altering the level of sodium channel expression as detected with a pan-Na channel antibody. (C) Quantification of changes in p38 activation following latency establishment and TNF-α treatment (* denotes p ≤ 0.05 vs. ACV-treated cells; n = 4)