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Survival rate of CD8α-deficient mice after 5-FU administration. CD8α+/− and CD8α−/− mice were treated i.p. with 600 or 800 mg of 5-FU per kg, and CD4+/− and CD4−/− mice were treated i.p. with 600 mg of 5-FU per kg. Twenty (600 mg/kg) or 10 mice (800 mg/kg) were used in each group. ∗, P < 0.05, and ∗∗, P < 0.01 compared with control litermates by the generalized Wilcoxon's test.
