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Growth of endogenous bacteria in CD8α-deficient mice administered 5-FU. Numbers of bacteria in the liver and spleen of CD8α+/− and CD8α−/− mice were determined on the indicated days after intraperitoneal administration of 600 mg of 5-FU per kg. Each point and vertical bar represent the mean ± standard deviation (SD) of six animals. ∗, P < 0.05, significant difference compared with CD8α+/− mice.
