Figure 4.

Comparison of simulation results obtained using two different implementations of the U.S. EPA (2013) PBPK model for methanol: (1) the original U.S. EPA (2013) (or “EPA IRIS Model”) implementation (dashed lines) and (2) the PBPK model template implementation (solid lines). Results are shown for the venous blood concentration of female rats exposed to five constant concentration levels of methanol (ranging from 1000 to 20 000 ppm) for 8 h. Simulation results from the original U.S. EPA (2013) implementation and published data of Perkins et al. (1996) (points) were obtained from Figure B-4, Panel A, of U.S. EPA (2013). Note that the respective predictions from each model implementation are nearly indistinguishable visually.