Figure 9.

Comparison of simulation results using two different implementations of the chloroform PBPK model of Sasso et al. (2013): (1) the original Sasso et al. (2013) implementation (dashed line) and (2) the PBPK model template implementation (solid line). Results are shown for venous blood, fat, liver, and kidney chloroform concentrations for rats given an oral bolus dose of 55 mg/kg of chloroform and simultaneously exposed to a constant concentration of 100 ppm of chloroform for 360 min. Simulations from the original Sasso et al. (2013) implementation and published data from Take et al. (2010) (points) were obtained from Figure 3 of Sasso et al. (2013). Note that the respective predictions from each model implementation are nearly indistinguishable visually.