Table 4.
Predictive ability of Week 12 Modified Multiplier of the Simple Endoscopic Score for Crohn’s Disease (MM-SES-CD) versus Simple Endoscopic Score for Crohn’s Disease (SES-CD) on Week 52 endoscopic remission (MM-SES-CD < 22.5) among participants with MM-SES-CD ≥ 22.5 at baseline (n = 100).
Endoscopic remission at Week 12 | AUC (95% CI) | ||
---|---|---|---|
Overall (n = 100) | Adalimumab (n = 51) | Placebo (n = 49) | |
Absence of mucosal ulcerations | 0.62 (0.57-0.67) | 0.63 (0.56-0.69) | 0.61 (0.54-0.68) |
SES-CD of 0 | 0.54 (0.51-0.57) | 0.55 (0.51-0.60) | 0.52 (0.49-0.55) |
SES-CD < 3 | 0.56 (0.52-0.59) | 0.58 (0.53-0.64) | 0.52 (0.49-0.55) |
SES-CD < 4 | 0.61 (0.56-0.65) | 0.66 (0.59-0.72) | 0.53 (0.49-0.57) |
MM-SES-CD < 22.5 | 0.71 (0.60-0.81) | 0.67 (0.33-1.00) | 0.68 (0.55-0.81) |
MM-SES-CD ≥ 20% reduction from baseline | 0.73 (0.62-0.84) | 0.72 (0.39-1.00) | 0.69 (0.56-0.83) |
MM-SES-CD ≥ 40% reduction from baseline | 0.69 (0.59-0.80) | 0.67 (0.33-1.00) | 0.65 (0.52-0.77) |
SES-CD ≥ 50% reduction from baseline | 0.62 (0.51-0.72) | 0.60 (0.27-0.94) | 0.55 (0.43-0.67) |