TABLE 2.
Serological reactivity of TB antigen combinations in smear-positive and smear-negative TB (HIV-negative) patients and healthy PPD-positive and PPD-negative individuals
| Patient status and origin | n | Smear | No. of samples positive by ELISAa
|
||
|---|---|---|---|---|---|
| 38 kDa | TbF6 | TbF6 + DPEP (%) | |||
| TB | |||||
| Brazil | 105 | + | 60 | 82 | 90 (85.7) |
| 39 | − | 14 | 21 | 25 (64.1) | |
| Total | 144 | 74 | 103 | 115 (79.8) | |
| Philippines | 40 | + | 14 | 21 | 30 (75.0) |
| 11 | − | 4 | 5 | 6 (54.6) | |
| Total | 51 | 18 | 26 | 36 (70.6) | |
| Turkey | 11 | + | 9 | 9 | 9 (81.8) |
| Sub-Saharan Africa | 66 | + | 27 | 44 | 47 (71.2) |
| Class II TB (PPD positive) | |||||
| Africa | 3 | − | 0 | 0 | 0 |
| Europe-Asiab | 6 | − | 0 | 0 | 0 |
| Southeast Asia | 7 | − | 2 | 1 | 0 |
| United States-Latin America | 41 | − | 3 | 2 | 3c |
| Total | 57 | 5 | 3 | 3 | |
| Class 0 or I (PPD negative) | |||||
| Africa | 1 | − | 0 | 0 | 0 |
| Europe-Asiab | 3 | − | 0 | 0 | 0 |
| Southeast Asia | 3 | − | 0 | 0 | 0 |
| United States-Latin America | 22 | − | 1 | 1 | 1c |
| Total | 29 | 1 | 1 | 1 | |
| Healthy donor, United States | 7/339 | 5/299 | 5/299 | ||
a
Positive values were greater than the mean + 3 SD of the healthy PPD-negative sera.
b
Primarily from Russia and its satellite regions endemic for TB.
c
At or near cutoff for ELISA.