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. 2025 Apr 7;42:102003. doi: 10.1016/j.bbrep.2025.102003

Fig. 1.

Fig. 1

Differential expression analysis of kinases and phosphatases

A. Volcano plot representing differentially regulated genes between CRPC patients (cbioportal, id: prad_su2c_2019, n = 208) and normal prostate (TCGA-GDC, id: TCGA-PRAD, n = 52), the left panel represents downregulated genes (log2FC < 1; FDR<0.01), and the right panel represents upregulated genes (log2FC > 1; FDR<0.01).

B. Venn diagram representing total number of differentially expressed genes along with up- and downregulated genes in CRPC patient samples.

C. Heatmap representation of patient level expression of differentially expressed kinases (prad_su2c_2019, n = 208 vs normal prostate, n = 52), with corresponding FDR and t-statistics plots, where upper section in the heatmap represents downregulated and lower section represents upregulated kinases (color red: high expression; blue: low expression).

D. Differential expression of phosphatases across CRPC patients (in prad_su2c_2019, n = 208 vs normal prostate, n = 52) represented in heatmap and corresponding FDR and t-statistics plots. Upper section in the heatmap represents downregulated phosphatases whereas lower section represents upregulated phosphatases (color red: High expression; blue: low expression).