Fig. 4.
Functional significance of KPPS and secondary validation
A. Co-occurrence of KPPS with top DEGs in CRPC patient data (prad_su2c_2019, n = 208 vs normal prostate, n = 52), where candidates on x-axis represent top DEGs and candidates on y-axis represents KPPS, and color intensity from yellow to red represents increasing -log10 values of p-values of each co-occurring event (selected co-occurrence events: p-value<0.05).
B. Fitness score of each KPPS across the prostate cancer cell lines (negative score: reduced fitness upon depletion of a gene; positive score: increased fitness upon depletion of a gene) (blue: reduced fitness; red: increased fitness).
C. Differential kinase expression in CRPC patients (TCGA-GDC, id: WCDT-MCRPC, n = 99) vs normal prostate samples (TCGA-GDC, id: TCGA-PRAD, n = 52) represented as heatmap, with corresponding FDR and t-statistics plots (color red: high expression; blue: low expression).
D. Differential phosphatase expression in CRPC patients (TCGA-GDC, id: WCDT-MCRPC, n = 99) vs normal prostate samples (TCGA-GDC, id: TCGA-PRAD, n = 52) represented as heatmap, with corresponding FDR and t-statistics plots (color red: high expression; blue: low expression).