Fig. 7.

RNA sequencing analysis in 22Rv1 cells upon MARK3 inhibition:

A. Volcano plot representing differentially expressed genes in 22Rv1 cells treated with DMSO or MARK3 inhibitor, PCC0208017.

B. GSEA plots showing enrichment of cancer hallmark gene sets; NES: Normalized Enrichment Score.

C. qRT-PCR analysis of AR-V7 target genes in cells treated with DMSO control or PCC0208017. (p-value: ∗∗0.01)

D. qRT-PCR analysis of KPPS genes in cells treated with DMSO control or PCC0208017. (p-value: ∗∗0.01).