Table 3.
Comparisons of change over time and average change in mean (standard deviation) of digital spiral drawing measures between THC/CBD and placebo arms at each time point after two-week treatment at visits 4 and 8 using linear mixed-effects models by treatment arm.
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|---|---|---|---|---|
| OUTCOMEa | χ2 (DF) | P-VALUEb | ADJUSTED P-VALUEc | |
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| Change over time (from baseline to time = 230 minutes after dose) | SPR (Amplitude, max) (mm) | 9.64 (7) | 0.21 | 0.63 |
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| SPR (Amplitude, mean) (mm) | 3.69 (7) | 0.81 | 0.81 | |
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| SPR Power (mm/s)2/Hz | 5.70 (7) | 0.57 | 0.81 | |
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| Average change from baseline to the last four time points (60 100, 200, 230 minutes after dose) | SPR (Amplitude, max) (mm) | 2.81 (1) | 0.093 | 0.15 |
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| SPR (Amplitude, mean) (mm) | 0.77 (1) | 0.38 | 0.38 | |
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| SPR Power (mm/s)2/Hz | 2.71 (1) | 0.10 | 0.15 | |
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Note: alog10 transformation prior to analysis; bp-value for interaction effect; cp-values were adjusted for multiple related outcomes using the Benjamini-Hochberg method; Abbreviations: SPR = digital spirography; df = degrees of freedom.