Table 2.

Gene ontology (GO) enrichment analysis of the biological processes, molecular functions, and cellular components from the analyzed clusters containing secretome proteins that were regulated by incubation with urate for 24 h.

Cluster 1 (n = 123)			Cluster 2 (n = 21)
Biological process	# of proteins	-log(p-value)	Biological process	# of proteins	-log(p-value)
inflammatory response regulation	26	6.39	extracellular matrix protein	6	5.94
cellular component organization	34	4.05	cell adhesion	9	2.52
cytokine signaling	14	2.43	response to wounding	6	2.05
RNA processing	17	2.39	extracellular matrix	5	1.92
regulation of proteolysis	12	1.48	cell projection	8	1.83
protein folding	5	1.45	cell migration	7	1.72
Molecular function	# of proteins	-log(p-value)	Molecular Function	# of proteins	-log(p-value)
cadherin binding	21	11.66	extracellular matrix	6	4.12
cell adhesion molecule binding	22	8.60	calcium ion binding	7	2.06
protein binding	114	7.92	proteoglycan binding	3	1.95
nucleic acid binding	51	5.15	fibronectin binding	3	1.91
actin binding	15	4.45	peptidase activator activity	3	1.62
unfolded protein binding	6	1.81	laminin interactions	2	1.34
Cellular component	# of proteins	-log(p-value)	Cellular component	# of proteins	-log(p-value)
extracellular space	78	29.44	extracellular region	18	6.43
cytoplasm	108	10.72	basement membrane	5	4.77
focal adhesion	20	9.68	lysosomal lumen	4	3.28
cell junction	36	6.17	vesicle	13	2.52
secretory vesicle	24	6.03	cell adhesion	3	2.46
nuclear lumen	50	4.26	laminin complex	2	2.25