Table 3.

Gene ontology (GO) enrichment analysis of the biological processes, molecular functions, and cellular components from the analyzed clusters containing lysate proteins that were regulated by incubation with urate for 1:30 h.

Cluster 1 (n = 61)			Cluster 2 (n = 297)
Biological process	# of proteins	-log(p-value)	Biological process	# of proteins	-log(p-value)
DNA repair	11	5.40	translation	40	17.83
response to stress	22	4.84	ribosome biogenesis	15	5.50
DNA replication initiation	4	3.41	protein folding	17	4.96
RNA transport	5	2.01	cell adhesion	34	3.71
response to chemical	18	1.80	cell migration	31	2.75
recombinational repair	4	1.44	extracellular matrix organization	14	2.22
regulation of DNA replication	4	1.40	response to unfolded protein	8	1.53
			NADP metabolic process	3	1.53
			cell redox homeostasis	5	1.51
			proteolysis	19	1.47
Molecular Function	# of proteins	-log(p-value)	Molecular function	# of proteins	-log(p-value)
RNA nuclease activity	7	5.79	structural constituent of ribosome	32	21.20
helicase activity	5	4.36	cadherin binding	37	18.16
cadherin binding	7	3.31	oxidoreductase activity	30	4.28
nucleic acid binding	18	1.92	DNA binding	3	4.09
peroxiredoxin activity	2	1.68	laminin binding	7	3.90
			protein folding chaperone	7	3.19
			protein disulfide isomerase activity	4	2.76
			extracellular matrix binding	7	2.54
			ubiquitin-like protein binding	14	1.68
			peroxiredoxin activity	3	1.58
Cellular component	# of proteins	-log(p-value)	Cellular component	# of proteins	-log(p-value)
extracellular organelle	13	1.95	cytosol	175	31.66
extracellular vesicle	13	1.91	focal adhesion	52	29.13
extracelular exosome	13	1.83	ribosome	34	19.72
secretory granule	8	1.71	endoplasmic reticulum	61	6.32
vesicle lumen	5	1.60	cytoplasmic vesicle	66	5.03
			basement membrane	10	4.33
			cell-cell junction	21	3.32
			proteasome complex	7	2.87
			nucleus	134	2.05
			cell surface	25	1.64