Table 2. AChE and BuChE inhibition and antioxidant activity of synthesized compounds (3a–3o).

Compounds	AChE IC50 ± SE (μM)	BuChE IC50 ± SE (μM)	Selectivity ratio	% Free radical scavenging, mean ± SE (μM)
				50 μM	100 μM
3a	1.920 ± 0.065	0.865 ± 0.038	2.22	09.42 ± 0.291	19.43 ± 0.421
3b	1.634 ± 0.066	0.0285 ± 0.019	57.33	17.24 ± 0.521	32.83 ± 0.139
3c	2.145 ± 0.095	1.871 ± 0.074	1.15	15.41 ± 0.422	28.23 ± 0.420
3d	3.905 ± 0.091	0.575 ± 0.054	6.79	20.59 ± 0.318	42.41 ± 0.281
3e	8.633 ± 0.082	3.829 ± 0.065	2.25	16.35 ± 0.522	33.13 ± 0.138
3f	27.27 ± 0.010	20.983 ± 0.069	1.30	14.42 ± 0.136	29.52 ± 0.361
3g	14.73 ± 0.010	19.78 ± 0.010	0.74	17.28 ± 0.428	31.51 ± 0.411
3h	2.341 ± 0.082	6.842 ± 0.042	0.34	15.19 ± 0.291	32.11 ± 0.220
3i	15.37 ± 0.010	18.84 ± 0.013	0.82	07.31 ± 0.428	12.45 ± 0.310
3j	8.397 ± 0.060	4.252 ± 0.029	1.97	16.62 ± 0.252	33.24 ± 0.194
3k	15.033 ± 0.012	19.831 ± 0.042	0.76	05.13 ± 0.503	09.69 ± 0.352
3l	1.928 ± 0.010	2.731 ± 0.042	0.71	07.52 ± 0.218	15.55 ± 0.153
3m	2.554 ± 0.012	0.952 ± 0.052	2.68	05.92 ± 0.422	11.53 ± 0.213
3n	6.042 ± 0.018	1.053 ± 0.026	5.74	12.34 ± 0.248	27.52 ± 0.520
3o	16.74 ± 0.068	25.93 ± 0.033	0.65	14.83 ± 0.310	29.42 ± 0.351
Donepezil	2.019 ± 0.068	17.38 ± 0.028	0.12	—	—
Tacrine	29.84 ± 0.04	28.49 ± 0.02	—	—	—
Ascorbic acid	—	—	—	45.83 ± 1.030	82.01 ± 1.42