Table 1.

Effect of SEB on health and survival of WT and ITK null mice. Mice (WT or ITK null) were injected with the indicated amount of LPS, followed 4 hours later by 50 μg SEB, both delivered Ip. Alternatively, mice were injected with 20 mg. D-Gal and 50 μg SEB at the same time. All injections were delivered intraperitoneally. Mice were then monitored for the presence of ruffled fur, mucous in feces and lethargy. *mice had ruffled fur, mucous in feces and were lethargic. **mouse died over the course of the experiment. ***mouse had to be euthanized due to severity of sickness.

Mice	Challenge	# Sick/n*	# Dead/n
WT	50 μg SEB + 150 μg LPS	14/15	1/15**
ITK-/-	50 μg SEB + 150 μg LPS	11/12	1/12***
WT	50 μg SEB + 20 mg D-Gal	10/11	1/11**
ITK-/-	50 μg SEB + 20 mg D-Gal	11/11	0/11