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. 2005 Jun 22;5:19. doi: 10.1186/1475-2867-5-19

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Copyright © 2005 Ifon et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Upregulated genes in PC3 cell line stably expressing U94. Two clones of G418 resistant PC3 cell lines transfected with plasmid pBk-U94 (tests 1 and 2) and a clone transfected with plasmid pBK-CMV (reference) were used for cDNA microarray studies. Each experiment was performed in triplicate and the results are mean ± SD. Notice the dramatic upregulation of FN 1 (91 ± 16-fold). A subset of other genes was also upregulated, but genes of interest in this study (> 6-fold change) include: SERPINE 2 (7 ± 1-fold); and ADAMTS 1 (7 ± 2-fold).