Table 3.

Median OS stratified by ALBI grades, BCLC stages, and GNRI

Variables	N	Median OS (95% CI)	p value
ALBI			<0.001
Grade 1	7,409	6.28 (6.01–6.58)
Grade 2	7,445	1.80 (0.68–1.91)
Grade 3	1,562	0.40 (0.34–0.47)
BCLC			<0.001
Stage 0/A	5,132	7.79 (7.46–8.12)
Stage B	2,608	2.63 (2.43–2.79)
Stage C	5,289	0.81 (0.75–0.85)
Stage D	968	0.20 (0.17–0.22)
ALBI+GNRI			<0.001
ALBI 1 + GNRI >105	5,239	7.42 (6.99–7.84)
ALBI 1 + GNRI ≤105	2,170	4.48 (4.05–4.85)
ALBI 2 + GNRI >90	5,639	2.21 (2.08–2.36)
ALBI 2 + GNRI ≤90	1,806	0.85 (0.76–1.03)
ALBI 3	1,562	0.40 (0.34–0.47)
BCLC 0/A			<0.001
ALBI 1 + GNRI >105	2,397	N/A (N/A)
ALBI 1 + GNRI ≤105	777	8.77 (8.13–9.62)
ALBI 2 + GNRI >90	1,589	5.41 (5.12–5.84)
ALBI 2 + GNRI ≤90	280	3.65 (2.93–4.33)
ALBI 3	89	3.17 (2.31–4.73)
BCLC B			<0.001
ALBI 1 + GNRI >105	878	4.26 (3.84–4.73)
ALBI 1 + GNRI ≤105	445	2.72 (2.32–3.17)
ALBI 2 + GNRI >90	881	2.04 (1.82–2.33)
ALBI 2 + GNRI ≤90	278	1.04 (0.74–1.32)
ALBI 3	126	0.74 (0.55–1.01)
BCLC C			<0.001
ALBI 1 + GNRI >105	1,131	2.39 (2.12–2.67)
ALBI 1 + GNRI ≤105	615	1.26 (1.08–1.52)
ALBI 2 + GNRI >90	2,224	0.60 (0.56–0.66)
ALBI 2 + GNRI ≤90	854	0.40 (0.35–0.45)
ALBI 3	465	0.34 (0.29–0.38)
BCLC D			0.082
ALBI 1 + GNRI >105	13	1.10 (0.24–2.76)
ALBI 1 + GNRI ≤105	16	0.63 (0.33–0.85)
ALBI 2 + GNRI >90	158	0.18 (0.16–0.23)
ALBI 2 + GNRI ≤90	109	0.26 (0.17–0.37)
ALBI 3	672	0.18 (0.16–0.21)

ALBI, albumin-bilirubin; BCLC, Barcelona Clinic Liver Cancer; GNRI, geriatric nutritional risk index; OS, overall survival; CI, confidence interval.