Table 4.
Univariate and multivariate analyses of association between GNRI and survival
| Subjects | Model 0 | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| crude HR (95% CI) | crude P | aHR (95% CI) | adjusted P | aHR (95% CI) | adjusted P | |
| ALBI grade 1 and 2 (n = 14,854) | ||||||
| Low GNRI (n = 3,976) | Reference | Reference | Reference | |||
| High GNRI (n = 10,878) | 0.700 (0.670–0.732) | <0.001 | 0.719 (0.688–0.752) | <0.001 | 0.775 (0.733–0.820) | <0.001 |
| Total patients (n = 16,416) | ||||||
| ALBI 3 (n = 1,562) | Reference | Reference | Reference | |||
| ALBI 2 + GNRI ≤90 (n = 1,806) | 0.783 (0.728–0.842) | <0.001 | 0.715 (0.665–0.769) | <0.001 | 0.887 (0.812–0.968) | 0.007 |
| ALBI 2 + GNRI >90 (n = 5,639) | 0.495 (0.466–0.526) | <0.001 | 0.471 (0.443–0.501) | <0.001 | 0.717 (0.665–0.773) | <0.001 |
| ALBI 1 + GNRI ≤105 (n = 2,170) | 0.306 (0.283–0.330) | <0.001 | 0.288 (0.267–0.311) | <0.001 | 0.420 (0.382–0.460) | <0.001 |
| ALBI 1 + GNRI >105 (n = 5,239) | 0.193 (0.181–0.207) | <0.001 | 0.186 (0.173–0.199) | <0.001 | 0.311 (0.286–0.338) | <0.001 |
Model 0, not adjusted; model 1, adjusted for age and sex; model 2, adjusted for age, sex, BMI, platelet count, ALBI grade, BCLC stages, etiology, and AFP.
GNRI, geriatric nutritional risk index; HR, hazard ratio; CI, confidence interval; ALBI, albumin-bilirubin; BMI, body mass index; BCLC, Barcelona Clinic Liver Cancer.