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. 2025 Feb 22;12(15):2412881. doi: 10.1002/advs.202412881

Figure 4.

Figure 4

Nanovaccines induce antitumor effects in ovarian cancer by improving the immune microenvironment. A) Schematic illustration of the treatment approach for subcutaneous ovarian cancer tumor models. B–D) Changes in tumor size, volume, and weight of ID8 ovarian cancer following different treatments as indicated (n = 8). E) Survival curves of mice in different groups observed over a continuous 60 d period (n = 7). F–H) Proportions of M2/M1 macrophages (CD206/CD80) in different groups of ID8 tumor tissues, assessed by multiplex immunohistochemistry and flow cytometry (n = 4), scale bar: 20 µm. I,J) Proportion of CD8a+ T cells in different groups of ID8 tumor tissues, determined by flow cytometry (n = 4). K,L) Immunohistochemical staining and statistical analysis of CD47 in the different groups, scale bar: 50 µm. Data are presented as mean ± SD, analyzed using an unpaired two‐sided Student's t test (ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001).