Table 3.
Mean (SE) adjusted scores for primary and secondary outcomes by allocated treatment at three and 12 months
|
3 months
|
12 months
|
|||||
|---|---|---|---|---|---|---|
| Outcomes measures | Motivational group | Social network group | Difference in favour of social group (95% CI) | Motivational group | Social network group | Difference in favour of social group (95% CI) |
| Days abstinent (%) | 42.3 (2.56) (n=393) | 43.2 (2.63) (n=293) | 0.90 (−3.98 to 5.78) | 45.4 (2.98) (n=351) | 46.6 (3.06) (n=261) | 1.19 (−4.50 to 6.88) |
| No of drinks per drinking day | 17.6 (0.89) (n=361) | 18.2 (0.92) (n=263) | −0.53 (−2.22 to 1.17) | 18.7 (1.11) (n=303) | 19.8 (1.15) (n=217) | −1.14 (−3.22 to 0.95) |
| Log γ-glutamyl transferase | 3.87 (0.070) (n=331) | 3.90 (0.070) (n=259) | −0.033 (−0.163 to 0.097) | 4.01 (0.0941) (n=293) | 4.00 (0.0992) (n=214) | 0.010 (−0.170 to 0.189) |
| Leeds dependence questionnaire (0-30, 0=best) | 12.0 (0.65) (n=367) | 11.8 (0.67) (n=275) | 0.24 (−0.99 to 1.46) | 10.6 (0.728) (n=332) | 11.2 (0.766) (n=231) | −0.64 (−2.02 to 0.74) |
| Alcohol problems questionnaire (0-23, 0=best) | 6.85 (0.41) (n=371) | 6.79 (0.42) (n=280) | 0.06 (−0.71 to 0.83) | 5.90 (0.467) (n=326) | 6.38 (0.489) (n=233) | −0.48 (−1.36 to 0.40) |
| EQ-5D (<0 to 1, 1=best) | 0.631 (0.021) (n=359) | 0.626 (0.022) (n=272) | −0.005 (−0.045 to 0.035) | 0.623 (0.025) (n=317) | 0.592 (0.026) (n=230) | −0.031 (−0.079 to 0.016) |
| General health questionnaire 28 (0-84, 0=best) | 31.6 (1.43) (n=364) | 30.9 (1.47) (n=274) | 0.71 (−1.98 to 3.40) | 28.6 (1.63) (n=324) | 31.2 (1.72) (n=234) | −2.64 (−5.73 to 0.44) |
| SF-36 (mean 50, SD 10, higher=better): | ||||||
| Mental component | 36.9 (1.11) (n=341) | 36.3 (1.12) (n=263) | −0.56 (−2.63 to 1.50) | 39.5 (1.26) (n=299) | 37.9 (1.30) (n=221) | −1.56 (−3.88 to 0.76) |
| Physical component | 47.3 (0.68) (n=341) | 48.6 (0.69) (n=263) | 1.31 (0.05 to 2.57) | 47.2 (0.80) (n=299) | 47.9 (0.82) (n=221) | 0.68 (−0.79 to 2.16) |
Adjusted by analysis of covariance for corresponding baseline score, centre, use of detoxification, three goals reported at randomisation (to abst ain, to abstain through disulfiram, and to use acamprosate.