Table 2.
Baseline endoscopic findings in the study patients.
| Variable | Total (n = 233) | CKD-495 75 mg (n = 52) | CKD-495 150 mg (n = 44) | Placebo (n = 47) | Stillen® 60 mg (n = 48) | Rebamipide100 mg (n = 42) | p valuea | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | n | % | n | % | |||
| Erosion grade (Baseline) |
Grade 1 | — | — | — | — | — | — | — | — | — | — | — | — | 0.2177 |
| Grade 2 | 126 | 54.08 | 31 | 59.62 | 29 | 65.91 | 22 | 46.81 | 23 | 47.92 | 21 | 50.00 | ||
| Grade 3 | 63 | 27.04 | 16 | 30.77 | 9 | 20.45 | 13 | 27.66 | 16 | 33.33 | 9 | 21.43 | ||
| Grade 4 | 44 | 18.88 | 5 | 9.62 | 6 | 13.64 | 12 | 25.53 | 9 | 18.75 | 12 | 28.57 | ||
|
| ||||||||||||||
| Edema grade (Baseline) |
Grade 1 | 161 | 69.10 | 36 | 69.23 | 33 | 75.00 | 31 | 65.96 | 33 | 68.75 | 28 | 66.67 | 0.9014 |
| Grade 2 | 72 | 30.90 | 16 | 30.77 | 11 | 25.00 | 16 | 34.04 | 15 | 31.25 | 14 | 33.33 | — | |
|
| ||||||||||||||
| Redness grade (Baseline) |
Grade 1 | 119 | 51.07 | 31 | 59.62 | 20 | 45.45 | 20 | 42.55 | 25 | 52.08 | 23 | 54.76 | 0.2832 |
| Grade 2 | 78 | 33.48 | 13 | 25.00 | 18 | 40.91 | 20 | 42.55 | 17 | 35.42 | 10 | 23.81 | — | |
| Grade 3 | 29 | 12.45 | 7 | 13.46 | 5 | 11.36 | 7 | 14.89 | 5 | 10.42 | 5 | 11.90 | — | |
| Grade 4 | 7 | 3.00 | 1 | 1.92 | 1 | 2.27 | 0 | 0.00 | 1 | 2.08 | 4 | 9.52 | — | |
|
| ||||||||||||||
| Hemorrhage grade (Baseline) |
Grade 1 | 163 | 69.96 | 33 | 63.46 | 31 | 70.45 | 35 | 74.47 | 37 | 77.08 | 27 | 64.29 | 0.3221 |
| Grade 2 | 36 | 15.45 | 14 | 26.92 | 7 | 15.91 | 4 | 8.51 | 5 | 10.42 | 6 | 14.29 | — | |
| Grade 3 | 23 | 9.87 | 2 | 3.85 | 5 | 11.36 | 4 | 8.51 | 6 | 12.50 | 6 | 14.29 | — | |
| Grade 4 | 7 | 3.00 | 1 | 1.92 | 1 | 2.27 | 3 | 6.38 | 0 | 0.00 | 2 | 4.76 | — | |
| Grade 5 | 4 | 1.72 | 2 | 3.85 | 0 | 0.00 | 1 | 2.13 | 0 | 0.00 | 1 | 2.38 | — | |
aChi-square test for intergroup comparison.