Table 1.

Pharmacokinetic parameters of angiotensin II receptor blockers^*

Drug	Active metab	Bioavail (%)	Food effect	Half-life (hrs)		Protein binding (%)		Route of elimination (%)
				Drug	Metab	Drug	Metab	Renal	Hepatic
Losartan	Yes	33	No	2	6–9	98.7	99.8	35	60
Valsartan	No	25	Yes	9	—	95	—	13	83
Irbesartan	No	70	No	11–15	—	90–95	—	20	80
Candesartan	Yes	42	No	3.5–4.0	3–11	99.5	—	33	67
Telmisartan	No	43	No	24	—	>99	—	0.5	>97
Eprosartan	No	15	No	5–7	—	98	—	7	90
Olmesartan	Yes	26	No	˜13	—	>99	—	35–50	50–65

*Adapted from references 2 and 3. Metab indicates metabolite; bioavail, bioavailability.