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. 2024 Sep-Oct;14(5):600–616. doi: 10.22038/AJP.2024.24271

Table 5.

The best docking results for the spike protein with drug-like characteristics

Compounds Binding Energy (kcal/mol) MW Donor
HB
Accept
HB
QPlog
Po/w
PSA Type of compound
Suramin -9.7 1297.263 12 36 -0.965 508.544 Polysulphonated naphthylurea
Amentoflavone -9.1 538.466 4 7.5 2.81 194.19 Glycosylated flavonoids
Sotetsuflavone -8.5 552.493 3 7.5 3.524 180.755 Biflavonoid
Chebulagic_acid -8.4 954.672 13 26.15 -3.9 470.728 Benzopyran tannin
Robustaflavone -8.4 538.466 4 7.5 2.957 193.616 Glycosylated flavonoids
Iguesterin -8.1 404.591 1 2.75 5.518 49.966 quinonoid triterpene
Eugeniin -7.9 938.672 15 22.95 -3.391 474.199 Ellagitannin
Polyphyllin_I -7.8 855.027 8 25.3 1.026 219.105 Triterpenoids
Hypericin -7.7 504.452 4 6.5 2.132 156.274 Anthraquinone
Verbascoside -7.7 624.594 9 20.3 -1.537 252.529 caffeoyl phenylethanoid glycoside
3B-Friedelanol -7.6 428.740 1 1.7 7.124 17.623 Triterpenoids
Astragaloside_A -7.6 784.980 9 21.9 0.484 207.345 Saponin
Topsentin -7.6 342.356 3 3.250 3.285 99.250 Alkaloids