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. 2025 Apr 19;15:13519. doi: 10.1038/s41598-025-97623-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Machine learning algorithm construction of MDD diagnostic model. (A) Identification of MDD feature genes using 113 machine learning algorithms; (B) Box plots of expression levels of 6 key genes; (C) Residual plot of MDD regression model; (D) Cook’s distance test plot of MDD regression model; (E) Bar plot of coefficients in MDD regression model; (F) Bar plot of MDD regression model scores for MDD patients and normal individuals; (G) ROC curves of the five datasets and the combined dataset (meta).