TABLE 3.
Comparison of variations in HP0638 CT repeat region sequences among the 109 H. pylori strains, grouped by HP0638 frame status
| HP0638 status | No. (%) of cagA-positive strains | No. of CT repeats | No. of strains by geographic regiona
|
|||
|---|---|---|---|---|---|---|
| East Asia (n = 46) | India (n = 8) | Western countries (n = 55) | Total (n = 109) | |||
| In frame (n = 89) | 89 (100) | 3 + 1 | 31 | 2 | 0 | 33 |
| <4 (other than 3 + 1) | 11 | 2 | 0 | 13 | ||
| 5 | 4 | 0 | 2 | 6 | ||
| 6 | 0 | 4 | 24 | 28 | ||
| 8 | 0 | 0 | 1 | 1 | ||
| 9 | 0 | 0 | 7 | 7 | ||
| 12 | 0 | 0 | 1 | 1 | ||
| Total | 46 | 8 | 35 | 89 | ||
| Out of frame (n = 20) | 4 (20) | 4 | 0 | 0 | 1 | 1 |
| 5 | 0 | 0 | 3 | 3 | ||
| 7 | 0 | 0 | 7 | 7 | ||
| 8 | 0 | 0 | 4 | 4 | ||
| 9 | 0 | 0 | 2 | 2 | ||
| 10 | 0 | 0 | 2 | 2 | ||
| 12 | 0 | 0 | 1 | 1 | ||
| Total | 0 | 0 | 20 | 20 | ||
a
For values shown in boldface, the distribution of CT repeats was significantly (P < 0.001) different between East Asia isolates (all 46 had ≤5 repeats) and Western isolates (33 of 35 had ≥6 repeats).