Table 3.

Efficacy evaluation of the dichotomous variables

Efficacy variables	Treatment group	N	Number (%) of participants	p-value	Number-needed-to-treat (95% CI)
50% reduction in pain	Topical diclofenac	105	46 (43.8)	0.004	5 (3–17)
	Vehicle control	107	27 (25.2)
OMERACT-OARSI responder*	Topical diclofenac	105	69 (65.7)	0.017	6 (3–33)
	Vehicle control	107	53 (49.5)
Good or very good PGA response	Topical diclofenac	105	46 (43.8)	<0.0001	4 (3–7)
	Vehicle control	107	18 (16.8)

*A responder is defined as a participant with ≥ 50% improvement in pain or function that was ≥ 20% of the scale, or ≥ 20% improvement in at least two of pain, function or patient global assessment that was ≥ 10% of the scale.